MLH1/PMS2 Analyte Control

MLH1 PMS2 Histology Slide Image

    • For Research Use Only
    • 2 Cores, one with intact expression for MLH1 and PMS2, one with loss of MLH1 and PMS2 expression

Product Options:

Part # HCL044 2 slides $19.00
Part # HCL045 5 slides $41.00
Part # HCL046 1 block $727.00

HistoCyte Laboratories’ MLH1/PMS2 Analyte Control contains 2 cell lines, one with intact expression for MLH1 and PMS2 and one with loss of expression for MLH1 and PMS2. This two core product is a cost effective means of controlling for MLH1 and PMS2 assays over the four core MMR Analyte Control.  However, it cannot be used with the other MMR assays.  These cell lines are derived from the following tumors:

Cell line A: Breast adenocarcinoma

Cell line B: Prostate carcinoma

  1. Cells are fixed in 10% neutral buffered formalin and paraffin wax embedded.
  2. Sections are cut at 4µm, mounted on positively charged slides and dried overnight at 37ºC.
  3. Cell microarrays (CMA) contain cores that are 1.5-2mm in diameter and 3-3.5mm in length.  It is possible to obtain over 300 sections depending on thickness.